Identifying acute myeloid leukemia gene mutations may indicate risk, best treatment
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 23-Mar-2012
[ | E-mail | 
Share ]
Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
TAMPA, Fla. An international group of researchers, including those from Moffitt Cancer Center in Tampa, Fla., have published a paper in the March 14 issue of the New England Journal of Medicine reviewing the results of a study that analyzed mutations in 18 genes of 398 patients who had acute myeloid leukemia (AML). They found that several mutated genes predicted improved outcomes when patients with certain gene mutations were given high-dose induction chemotherapy. Their findings suggest that mutational profiling could potentially be used for both risk stratification and also in helping health care providers make therapeutic decisions for some AML patients.
“Previous studies have found that AML is a highly heterogenic disorder,” said study co-author Hugo F. Fernandez, a senior member at Moffitt and associate chief of Moffitt’s Blood and Marrow Transplantation Division. “Moreover, recent studies have revealed that a number of genetic mutations in AML patients might have prognostic value. The question of the presence of these gene mutations altering outcomes based on current therapy had not been answered to date.”
Their paper cites a clinical trial carried out by the Eastern Cooperative Oncology Group (ECOG) in which dose-intensified chemotherapy improved outcomes in two age sets of AML patients. Based on these findings, the research team hypothesized that carrying out mutational analysis of all known molecular alterations occurring in more than 5 percent of patients with AML might allow for the identification of distinct, molecularly defined subgroups of patients who might benefit from dose-intensified chemotherapy.
The laboratory research team subsequently performed a mutational analysis on diagnostic samples from 398 patients enrolled in the ECOG clinical trial they cited and used patients’ frozen sample cells for extraction and profiling. The researchers validated the results of this latter group of 104 patients.
“We found that intensification of the dose of anthracycline significantly improved outcomes and overall survival in patients with mutations in DNMT3A, NPM1 or MLL translocations,” said Fernandez. “This finding suggests that mutational profiling could be used to determine which AML patients will benefit from dose-intensive induction therapy.”
“Most importantly,” said Fernandez, “this study demonstrates how integrated mutational profiling of samples from a clinical trial cohort can advance understanding of the biologic characteristics of AML.”
###
About Moffitt Cancer Center
Follow Moffitt on Facebook: www.facebook.com/MoffittCancerCenter
Follow Moffitt on Twitter: @MoffittNews
Follow Moffitt on YouTube: MoffittNews
Located in Tampa, Moffitt Cancer Center is a National Cancer Institute-designated Comprehensive Cancer Center, which recognizes Moffitt’s excellence in research and contributions to clinical trials, prevention and cancer control. Moffitt is also a member of the National Comprehensive Cancer Network, a prestigious alliance of the country’s leading cancer centers, and is listed in U.S. News & World Report as one of “America’s Best Hospitals” for cancer.
Media release by Florida Science Communications
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 23-Mar-2012
[ | E-mail | Share ]
Contact: Ferdie De Vega
Ferdinand.DeVega@moffitt.org
813-745-7858
H. Lee Moffitt Cancer Center & Research Institute
TAMPA, Fla. An international group of researchers, including those from Moffitt Cancer Center in Tampa, Fla., have published a paper in the March 14 issue of the New England Journal of Medicine reviewing the results of a study that analyzed mutations in 18 genes of 398 patients who had acute myeloid leukemia (AML). They found that several mutated genes predicted improved outcomes when patients with certain gene mutations were given high-dose induction chemotherapy. Their findings suggest that mutational profiling could potentially be used for both risk stratification and also in helping health care providers make therapeutic decisions for some AML patients.
“Previous studies have found that AML is a highly heterogenic disorder,” said study co-author Hugo F. Fernandez, a senior member at Moffitt and associate chief of Moffitt’s Blood and Marrow Transplantation Division. “Moreover, recent studies have revealed that a number of genetic mutations in AML patients might have prognostic value. The question of the presence of these gene mutations altering outcomes based on current therapy had not been answered to date.”
Their paper cites a clinical trial carried out by the Eastern Cooperative Oncology Group (ECOG) in which dose-intensified chemotherapy improved outcomes in two age sets of AML patients. Based on these findings, the research team hypothesized that carrying out mutational analysis of all known molecular alterations occurring in more than 5 percent of patients with AML might allow for the identification of distinct, molecularly defined subgroups of patients who might benefit from dose-intensified chemotherapy.
The laboratory research team subsequently performed a mutational analysis on diagnostic samples from 398 patients enrolled in the ECOG clinical trial they cited and used patients’ frozen sample cells for extraction and profiling. The researchers validated the results of this latter group of 104 patients.
“We found that intensification of the dose of anthracycline significantly improved outcomes and overall survival in patients with mutations in DNMT3A, NPM1 or MLL translocations,” said Fernandez. “This finding suggests that mutational profiling could be used to determine which AML patients will benefit from dose-intensive induction therapy.”
“Most importantly,” said Fernandez, “this study demonstrates how integrated mutational profiling of samples from a clinical trial cohort can advance understanding of the biologic characteristics of AML.”
###
About Moffitt Cancer Center
Follow Moffitt on Facebook: www.facebook.com/MoffittCancerCenter
Follow Moffitt on Twitter: @MoffittNews
Follow Moffitt on YouTube: MoffittNews
Located in Tampa, Moffitt Cancer Center is a National Cancer Institute-designated Comprehensive Cancer Center, which recognizes Moffitt’s excellence in research and contributions to clinical trials, prevention and cancer control. Moffitt is also a member of the National Comprehensive Cancer Network, a prestigious alliance of the country’s leading cancer centers, and is listed in U.S. News & World Report as one of “America’s Best Hospitals” for cancer.
Media release by Florida Science Communications
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-03/hlmc-iam032312.php
dolly parton i will always love you beverly hilton hotel whitney houston found dead i will always love you whitney houston 2012 grammy awards powerball results pebble beach golf
Strauss-Kahn held in prostitution probe (AP)
[unable to retrieve full-text content]
AP – French police questioned former International Monetary Fund chief Dominique Strauss-Kahn all day Tuesday in a probe into a suspected hotel prostitution ring.
annette funicello family bipolar disorder smallville season 10 kotaku tom welling pizzahut
dacvb.info ? You May Survive Your Home Improvement Undertaking …
Profitable Home Improvement Starts With The Following Tips
Renovation is the process of producing adjustments to versions houses, possibly through fix or remodelling. Home improvement projects might be little, like adding sealant into a windowpane. They can also be significant tasks, like introducing new flooring to surfaces. The information in this article ought to assist you with renovation, no matter the size of the job.
Usually do not underestimate the need for a superior quality door. It will be the initial and final thing your invited guests will discover. You can reduce quite a lot of warmth using a poorly in good shape and uninsulated door. In case your door frame or locks are outdated or badly produced, you get rid of security and safety and comfort.
If you are planning on using out a house improvement loan be sure to seek information. It has come to be progressively tougher to take out a property advancement mortgage loan which is unsecured which suggests you may have to make use of household as collateral. Make sure this can be something that you are ready to do.
When performing a significant household makeover and remodelling on the internal, remember to be steady along with your hardware through the house. If you are planning to get brushed nickel for your hinges and doorknobs, install similar computer hardware on the toilet cabinets, bath towel bars, and drawer pulls. It makes to get a a lot more regular and appealing appearance.
Discover ideas for renovating or redecorating from mags, colour swatches and home improvement demonstrates. Even if you will not be planning on a Do-it-yourself task straight away, trying to find and remembering the concepts you want to work with assures once you do take on the assignments, it will be a lot less demanding. In addition, you can purchase resources over time to propagate the expenditure as time passes.
Protection Sunglasses
Compelling stuff, we think ? what are your thoughts? safety glasses is an area that offers a huge amount for those who are serious or need to learn. It is really similar to other related topics that are important to people.
You never really know about any one element because there are a lot of varied situations. Do you know exactly the kind of information that will help? If not, then you should learn more about this. The rest of our talk will add more to what we have said so far.It is best to don protection sunglasses or goggles when cutting with a saw or any other driven products. Unless you put on protecting equipment for the view bits of the fabric you might be slicing or dust particles may become lodged in your eye or trigger irritation. In serious instances long lasting problems can be done for your eye.
It is wise to put on basic safety sunglasses or goggles when reducing by using a discovered or any other operated gear. If you do not use safety devices for the eyes pieces of the fabric you will be cutting or dust can be lodged within your eye or lead to irritation. In extreme cases long term damage can be done in your eye.
Something which would seem on the surface to become so simple can turn out getting amazingly complex if you?re not aware about the way to handle an activity. Painting can become a problem including a lot more lighting could keep you inside the darker. The information in this article can help you find out about renovation, so place these people to great use. The nice Gregorio H Roblow is a phenomenal author.
Source: http://dacvb.info/you-may-survive-your-home-improvement-undertaking-by-using-these-excellent-ideas/
randy couture vs lyoto machida pope john paul misery divine mercy sunday godzilla gaddafi son killed jon hamm
Rinspeed gives Smart Fortwo ED two extra wheels, more junk in the trunk
Rinspeed is a Swiss speed shop that is perhaps best known for making rather outlandish concept cars, from glorified golf carts to Bond-inspired amphibious autos. And now the company has unveiled its latest creation, the Dock+Go, a “backpack” for your Smart Fortwo ED. Essentially, Rinspeed has modified an existing Fortwo EV so that it can connect an extra axle to its derriere, providing extra trunk space, a hot box for pizza delivery or even extra speakers and infotainment options. Not only that, but the automotive add-on also packs extra oomph to give your mini EV additional range with a built-in fuel cell, battery or ICE.
The Fortwo that the Dock+Go mates with has itself gotten a bunch of show-worthy interior upgrades as well. It’s got a 12.1-inch in-dash monitor, infotainment system from Harman with Aha radio and gesture control, plus an incredibly safe smartphone cradle built into the steering wheel to give the Smart’s cockpit a second screen. Because it’s a concept, you won’t see the Dock+Go on the streets anytime soon, but you can see plenty more pictures of it at the source below. Oh, and should customer demand be sufficient, Rinspeed’s in talks with manufacturers to make it happen. What say you, dear readers, does a Fortwo EV with a fatter caboose appeal to you?
Rinspeed gives Smart Fortwo ED two extra wheels, more junk in the trunk originally appeared on Engadget on Mon, 20 Feb 2012 20:02:00 EDT. Please see our terms for use of feeds.
Permalink | 
Mercedes Benz | Email this | Comments
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/3aku1EVvEpc/
toyota prius seven pounds dante g8 bono weather louisville ky mavs
Office for iPad Is Reportedly Imminent [Ipad]
Online Movie Channels * When you Sit back and watch Satellite TV …
Sorry, Readability was unable to parse this page for content.
kony 2012 jim irsay the new ipad apple announcement indianapolis colts joseph kony joseph kony
Knicks’ Jeremy Lin makes 2nd straight SI cover (AP)
[unable to retrieve full-text content]AP – Covering Jeremy Lin has been easy for Sports Illustrated.
hcg diet weather st louis st louis weather kansas city weather dancing with the stars winner don t you forget about me biggest loser winner
kiwanis chatting: EzineArticles Alert: Arts-and-Entertainment …
This email alert is a service of EzineArticles.com. Should you no longer wish to receive these messages please go here to unsubscribe or send an email to:
leave-7154400-5823992.b453b75be4746eb18882587c1ebc4b36@lists.ezinearticles.com
To ensure delivery of this email alert to your inbox and to enable images to load in future mailings, please add alerts@ezinearticles.com to your e-mail address book or safe senders list.
New Alerts | Manage Your Alerts | EzineArticles.com
Postal address: EzineArticles.com, PO Box 12740 Green Bay WI 54307 USA
(C) Copyright 1999-2012 EzineArticles.com. All Rights Reserved.
Source: http://artphotomusic-cj.blogspot.com/2012/03/ezinearticles-alert-arts-and_4613.html
benetton ads cornucopia best buy black friday deals thanksgiving crafts matt cassel snowman playstation network down
Source: http://lyfocarevi.posterous.com/ezinearticles-alert-arts-and-entertainmentphi
heavy d dead heavy d dead alaska weather alaska weather gop debate live gop debate live nome alaska
Source: http://gailratliff.typepad.com/blog/2012/03/ezinearticles-alert-arts-and-entertainmentphilosophy-artphoto.html
election results 2011 election results 2011 board of elections board of elections senate bill 5 senate bill 5 joe paterno press conference
Source: http://kiwanis-chatting.blogspot.com/2012/03/ezinearticles-alert-arts-and.html
aaron carter black history month did groundhog see his shadow soul train don cornelius rod parsley barry sanders jr nick carter sister
Velorium Surged As Low Cost IT Outsourcing Company ? The …
Velorium is one of the leading IT outsourcing company offering low cost solutions to small to medium sized companies. The company has not limited itself to certain services but is offering diversified services related to business operations, finance, accounting, information and technology, design, marketing and much more. ?Velorium hires talented people; train, manage and retain them for specific needs of outsourcing?; narrated by a spokesperson at Velorium. Its list of services includes:
Information and Technology
Velorium provides extensive information and technology solutions that includes web programming, server management, software development, data management, database design, data integration, website maintenance and ERP/CRM implementation.
Accounting and Finance
One of the major problems that companies and business face is that most of their profit is drained out without knowing. With Velorium?s expert services in accounting and finance, clients can keep a keen eye on every penny spent on their business. Services include bookkeeping, data analysis, accounting, reports generation, Peachtree, Accpac, QuickBooks and Net Suite. Aside from these services, our experts will also help you out in cutting overheads and maximizing profits.
Business Operations
Most of the small to medium sized companies and businesses have problems in coping with their back-office operations due to their incapability to hire full time employees. Velorium offers its skilled services in business operations, which includes customer service, order processing, accounting, sales, marketing data entry and any other thing client, prefer.
Design
Velorium truly understands the importance of a website design and its impact on the business. For this reason the company has hired qualified and experienced designers who really make the website design professional and attractive for customers. Designing services include print design, broachers, company logo, 3Danimations, flyers, letterheads, PDF product manuals and website layout.
Marketing
Velorium is aware of the importance of marketing and have skilled the art of online marketing. Its marketing aim is not just to bring traffic on client?s website but also bring right kind of visitors. The company has expertise in Brand management, analytics PPC campaign management, copy writing, content writing and much more.
Source:http://www.sbwire.com/press-releases/sbwire-129818.htm
Source: http://www.theoutsourceblog.com/2012/03/velorium-surged-as-low-cost-it-outsourcing-company/
gina carano at last al green burger king delivery etta james at last john king obama sings al green